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Nasopharyngeal Cancer

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Nasopharyngeal cancer is one of the top ten cancers in Hong Kong that cannot be ignored. There are 600 to 800 cases of nasopharyngeal cancer in the city every year. Unlike many other cancers, nasopharyngeal cancer tends to occur at a relatively early age, with the peak incidence between 40 and 60 years old, considered the prime of one's life. The incidence rate is almost three times higher in males than in females. Compared to Western countries, nasopharyngeal cancer is more commonly found in Southern China.

In 2021, NPC was the fourteenth commonest cancer in Hong Kong, accounting for 2% of all new cancer cases. In addition, NPC was the ninth commonest cancer in men.

Cancer originates from one or more genetic mutations in the body, causing abnormal growth of normal cells, invading nearby structures, and spreading to other body parts. Nasopharyngeal cancer is caused explicitly by atypical squamous cells on the surface of the nasopharynx.

Symptoms

The early symptoms of nasopharyngeal cancer are similar to some upper respiratory tract diseases, such as rhinitis and sinusitis. If you suspect these early signs of nasopharyngeal cancer, you should get checked as soon as possible.

⚠️ Suppose you notice symptoms like tinnitus, hearing loss, frequent episodes of otitis media, persistent nasal congestion, bloody nasal or throat discharge, or the appearance of painless neck lumps. In that case, there is a chance you might have nasopharyngeal cancer, and you should seek prompt medical evaluation. When the tumour extends to the base of the skull and the brain, it can lead to problems such as headaches, facial numbness, double vision, and difficulty closing the jaw.

In more severe cases of nasopharyngeal cancer, complications can occur as the cancer cells grow and invade nearby structures such as the throat, brain, and bones. Additionally, cancer cells can spread to other parts of the body, leading to lymph node metastasis in the neck and affecting the lungs and liver. If you observe symptoms suggestive of nasopharyngeal cancer, early medical evaluation is essential.

Factors

Cancer originates from one or more genetic mutations within the body, which drive normal cells to grow abnormally, invade nearby structures, and spread to other parts of the body. Nasopharyngeal cancer, specifically, is caused by atypical squamous cells on the surface of the nasopharynx.

The following factors influence the likelihood of developing nasopharyngeal cancer:

Genetic factorsWhen there are genetic issues or unhealthy family habits, the risk of nasopharyngeal cancer is higher among siblings and close relatives of patients compared to the general population.
Viral infectionsEB virus, which is the pathogen for infectious mononucleosis, is prevalent worldwide. Most adults in Hong Kong have been exposed to this virus, often with mild symptoms. However, individuals with specific genetic predispositions are at a higher risk of developing nasopharyngeal cancer if they become infected. How the virus contributes to cancer is still under medical research.
Dietary habitsIn regions like South China, prolonged and excessive consumption of salted fish and smoked foods may contribute to the development of nasopharyngeal cancer.

In other words, to reduce the risk of nasopharyngeal cancer, one should focus on improving daily lifestyle habits, minimize excessive salt intake, and also consider avoiding smoking based on some data suggesting an increased risk associated with smoking.

nasopharyngeal cancer Hong Kong

Diagnosis

he doctor will first inquire about relevant symptoms and the patient's medical and family history to check for nasopharyngeal cancer. They will also thoroughly examine the ears, nose, and throat and check the neck for tumours. The doctor will use an endoscope to examine the nasopharynx if a tumour is found. If a cancer is also found in that area, a small tissue sample will be removed for microscopic examination to determine if it is malignant and to identify the cause.
 

The doctor will then perform a detailed assessment of the patient, including imaging tests, to check if the tumour has spread to the skull, brain, or nerves and to determine the stage of nasopharyngeal cancer. The evaluation typically involves three types of imaging:

  • MRI
    This large scan uses magnetic fields to produce detailed images of internal tissues and organs. Patients may need to be injected with a contrast agent to ensure more explicit photos. MRI is particularly effective at showing small lesions.
     
  • CT Scan
    This scan takes X-rays from different angles to create 3D images of the internal tissues, helping to assess whether the cancer has spread.
     
  • PET CT Scan
    After a small amount of radioactive contrast material is injected into the bloodstream, a scanner detects how the body's cells absorb and distribute glucose, identifying any abnormal cellular activity and determining if cancer has spread to other areas. The Epstein-Barr virus (EBV) gene test can also help predict the disease's progression and monitor its status.
     

Based on the size and extent of the tumour, nasopharyngeal cancer can be classified into different stages.

StagesAffected Areas
Stage IThe tumour is confined to the nasopharynx and has not spread to surrounding tissues.
Stage IIThe tumour has invaded nearby tissues on the side of the throat or has spread to the lymph nodes on one side of the nasopharynx but has not spread to distant areas.
Stage IIICancer cells have spread to the lymph nodes on both sides of the neck but have not spread to distant areas, or the tumour has extended to the skull or sinuses.
Stage IVA  The tumour has extended to the brain, invaded cranial nerves or has spread to lymph nodes above the collarbone or lymph nodes larger than 6 cm.
Stage IVBThe tumour has spread to distant areas, such as bones, liver, or lungs.

The primary purpose of staging nasopharyngeal cancer is to help doctors design a treatment plan, calculate the radiation dosage, and determine the appropriate treatment methods.

Treatments

The treatment of nasopharyngeal cancer primarily involves two methods: radiation therapy and chemotherapy, depending on the tumour's location, cancer staging, and the overall health of the patient. These two treatment methods can be used individually or in combination.

Radiation TherapyRadiation therapy is the primary treatment for patients with nasopharyngeal cancer who haven't experienced distant spread. It involves the use of high-energy X-rays to irradiate the tumour, effectively killing cancer cells. For patients with remote space, radiation therapy can also alleviate symptoms caused by the spread, such as bone pain.
ChemotherapyRadiation therapists create a plastic mould tailored to the patient's facial and head shape to secure the body for accurate radiation targeting. After wearing the plastic mould, patients undergo a computer scan to help doctors delineate the tumour and identify crucial organs to be avoided, such as the spinal cord and brainstem. Finally, a personalized plan is designed by a physicist or radiation therapist to determine the optimal angles and intensity of radiation.
SurgeryIn addition to the above two treatments, surgical removal of the tumour is also an option for treating nasopharyngeal cancer. However, because nasopharyngeal cancer is located deep within the head, the tumour is challenging to remove altogether. As a result, surgery is typically considered when the tumour persists, recurs, or when radiation therapy is ineffective. During surgery, nearby nerves may be affected, leading to potential side effects such as ear numbness, oral pain and dryness, jaw stiffness, and neck stiffness. It is advisable to undergo regular follow-up examinations, such as imaging scans or endoscopic evaluations, to monitor recovery progress.

HEAL Oncology Centre

We provide a variety of treatment options for nasal cancers, including surgery, chemotherapy, targeted therapy, immunotherapy, radiation therapy, and traditional Chinese medicine. Our multidisciplinary team of specialists will tailor the best treatment plan for each patient, providing comprehensive and holistic care to ensure you receive the best possible outcomes and support throughout your cancer treatment journey.

HEAL Oncology Centre

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